NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C^hi monocytes in pressure-overloaded hearts.

ABSTRACT: Heart failure is a major public health problem, and inflammation is involved in its pathogenesis. Inflammatory Ly6C^hi monocytes accumulate in mouse hearts after pressure overload and are detrimental to the heart; however, the types of cells that drive inflammatory cell recruitment remain uncertain. Here, we showed that a distinct subset of mouse cardiac fibroblasts became activated by pressure overload and recruited Ly6C^hi monocytes to the heart. Single-cell sequencing analysis revealed that a subset of cardiac fibroblasts highly expressed genes transcriptionally activated by the transcription factor NF-κB, as well as C-C motif chemokine ligand 2 (Ccl2) mRNA, which encodes a major factor in Ly6C^hi monocyte recruitment. The deletion of the NF-κB activ

SUBMITTER: Abe H 

PROVIDER: S-EPMC11536391 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature