Comparative Phylogenetic Analysis and Protein Prediction Reveal the Taxonomy and Diverse Distribution of Virulence Factors in Foodborne <i>Clostridium</i> Strains.

ABSTRACT:

Background

Clostridium botulinum and Clostridium perfringens, 2 major foodborne pathogenic fusobacteria, have a variety of virulent protein types with nervous and enterotoxic pathogenic potential, respectively.

Objective

The relationship between the molecular evolution of the 2 Clostridium genomes and virulence proteins was studied via a bioinformatics prediction method. The genetic stability, main features of gene coding and structural characteristics of virulence proteins were compared and analyzed to reveal the phylogenetic characteristics, diversity, and distribution of virulence factors of foodborne Clostridium strains.

Methods

The phylogenetic analysis was performed via composition vector and average nucleotide identity based methods.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11536399 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature