Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation.

ABSTRACT:

Background

Immune cell metabolism governs the outcome of immune responses and contributes to the development of autoimmunity by controlling lymphocyte pathogenic potential. In this study, we evaluated the metabolic profile of myelin-specific murine encephalitogenic T cells, to identify novel therapeutic targets for autoimmune neuroinflammation.

Methods

We performed metabolomics analysis on actively-proliferating encephalitogenic T cells to study their overall metabolic profile in comparison to resting T cells. Metabolomics, phosphoproteomics, in vitro functional assays, and in vivo studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), were then implemented to evaluate the effect of metabolic targeting on autoreactive T cell pat

SUBMITTER: Angiari S 

PROVIDER: S-EPMC11536535 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature