Unveiling the prognostic significance of malignant ascites in advanced gastrointestinal cancers: a marker of peritoneal carcinomatosis burden.

ABSTRACT:

Background

Ascites is common in advanced gastrointestinal cancers with peritoneal metastases (PM) and negatively impacts patient survival. No study to date has specifically evaluated the relationship between ascites, PM and survival outcomes in metastatic colorectal cancer (mCRC) and metastatic gastric cancer (mGC).

Objectives

This study aims to investigate and elucidate the relationship between malignant ascites, PM and survival outcomes in both mCRC and mGC patients.

Design

This is a retrospective analysis of prospectively collected clinical trial data of mCRC and mGC patients with PM.

Methods

We performed two pooled analyses, firstly of two Italian randomized trials enrolling patients with mCRC eligible for systemic therapy (TRIBE2; VALENTINO), and secondly

SUBMITTER: Provenzano L 

PROVIDER: S-EPMC11536604 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature