Assessment of Plasma Exovesicles and Prothrombotic Biomarkers Suggest Prethrombotic Conditions in Chagas Cardiomyopathy in Colombia.

ABSTRACT: Chagas cardiomyopathy (CCC) is associated with coagulation disorders that frequently culminate in thrombotic events, contributing to increased mortality rates in this clinical condition. Considering the demonstrated effect that extracellular vesicles (EVs) have on regulating inflammatory processes, coagulation, and angiogenesis, the present study aims to characterize plasma EVs and their relationship with coagulation disorders in patients with CCC. A total of 78 patients were assessed with 46.1% (36/78) representing the CCC group, 8.9% (7/78) with cardiomyopathy unrelated to Chagas disease (CM group), and 44.8% (35/78) comprising the control group, which included individuals without cardiomyopathy and negative for T. cruzi infection. Plasma EVs concentration (EVs/mL) for each indivi

SUBMITTER: Jaimes-Duenez JE 

PROVIDER: S-EPMC11536625 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature