A predictive model based on serum bicarbonate for cardiovascular events after initiation of peritoneal dialysis.

ABSTRACT:

Background

The risk of cardiovascular events (CVEs) in peritoneal dialysis (PD) patients is high, but varies widely among individuals. Metabolic acidosis is prevalent in PD patients and may be involved in the development of CVEs. The aim of the study was to evaluate serum bicarbonate as a risk factor and derive a model of new CVE.

Methods

A predictive model was established by performing an observational study in 187 PD patients obtained from the First Affiliated Hospital of Anhui Medical University. The variables were extracted using least absolute shrinkage and selection operator (LASSO) regression, and the modeling was developed using multivariable Cox regression.

Results

Left ventricular hypertrophy (HR = 1.965, 95%CI 1.086-3.557) and history of CVEs (HR = 2.435, 9

SUBMITTER: Li D 

PROVIDER: S-EPMC11536655 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature