The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia.

ABSTRACT:

Background

Follicular atresia significantly impairs female fertility and hastens reproductive senescence. Apoptosis of granulosa cells is the primary cause of follicular atresia. Pyroptosis and necroptosis, as additional forms of programmed cell death, have been reported in mammalian cells. However, the understanding of pyroptosis and necroptosis pathways in granulosa cells during follicular atresia remains unclear. This study explored the effects of programmed cell death in granulosa cells on follicular atresia and the underlying mechanisms.

Results

The results revealed that granulosa cells undergo programmed cell death including apoptosis, pyroptosis, and necroptosis during follicular atresia. For the first time, we identified the formation of a PANoptosome complex in porc

SUBMITTER: Wu H 

PROVIDER: S-EPMC11536665 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature