Definition of metafounders based on population structure analysis.

ABSTRACT:

Background

Limitations of the concept of identity by descent in the presence of stratification within a breeding population may lead to an incomplete formulation of the conventional numerator relationship matrix ( A ). Combining A with the genomic relationship matrix ( G ) in a single-step approach for genetic evaluation may cause inconsistencies that can be a source of bias in the resulting predictions. The objective of this study was to identify stratification using genomic data and to transfer this information to matrix A , to improve the compatibility of A and G .

Methods

Using software to detect population stratification (ADMIXTURE), we developed an iterative approach. First, we identified 2 to 40 strata ( k ) with ADMIXTURE, which we then introduced in a stepwise manne

SUBMITTER: Anglhuber C 

PROVIDER: S-EPMC11536677 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature