Proton Pump Inhibitors and Risk of COVID-19 Infection in Children.

ABSTRACT:

Objective

To evaluate the influence of proton pump inhibitor (PPI) use on COVID-19 susceptibility and severity in children.

Study design

This retrospective, case-control study included all children ≤21 years undergoing COVID-19 polymerase chain reaction testing at a tertiary children's hospital between March 2020 and January 2023. The main exposure was PPI usage. The primary outcome was COVID-19 infection. The secondary outcome was COVID-19 hospitalization. Log-binomial regressions were used to examine associations between PPI use and these outcomes.

Results

116 209 patients age 8.5 ± 6.2 years underwent 234 867 COVID-19 tests. Current PPI use was associated with a decreased risk of COVID-19 test positivity compared with PPI nonuse [RR 0.85 (95% CI 0.76, 0.94), P = .0

SUBMITTER: Hirsch S 

PROVIDER: S-EPMC11536706 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature