G-quadruplex formation in RNA aptamers selected for binding to HIV-1 capsid.

ABSTRACT: HIV-1 capsid protein (CA) is essential for viral replication and interacts with numerous host factors to facilitate successful infection. Thus, CA is an integral target for the study of virus-host dynamics and therapeutic development. The multifaceted functions of CA stem from the ability of CA to assemble into distinct structural components that come together to form the mature capsid core. Each structural component, including monomers, pentamers, and hexamers, presents a variety of solvent-accessible surfaces. However, the structure-function relationships of these components that facilitate replication and virus-host interactions have yet to be fully elucidated. A major challenge is the genetic fragility of CA, which precludes the use of many common methods. To overcome these constraints

SUBMITTER: Mayer MD 

PROVIDER: S-EPMC11536715 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature