Association between different proportions of crescents and the progression of IgA nephropathy (IgAN): a systematic review and meta-analysis.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is a complex renal disease with a highly variable clinical course. Identifying reliable prognostic markers is crucial for risk stratification and treatment decisions. This study aimed to understand the influence of different proportions of crescents (Cs) on the progression of IgAN.

Methods

Four databases (PubMed, Web of Science, Embase, and Cochrane Library) were searched until September 25, 2023. The study encompassed IgAN patients, focusing on kidney outcomes and end-stage kidney disease (ESKD). Statistical analysis included calculating hazard ratios (HR) for binary outcomes and examining publication bias.

Results

The meta-analysis involved thirteen studies comprising 11,849 patients. For kidney outcomes, crescent forma

SUBMITTER: Yu L 

PROVIDER: S-EPMC11536721 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature