Pyoverdine-antibiotic combination treatment: its efficacy and effects on resistance evolution in <i>Escherichia coli</i>.

ABSTRACT: Antibiotic resistance is a growing concern for global health, demanding innovative and effective strategies to combat pathogenic bacteria. Pyoverdines, iron-chelating siderophores produced by environmental Pseudomonas spp., present a novel class of promising compounds to induce growth arrest in pathogens through iron starvation. While we previously demonstrated the efficacy of pyoverdines as antibacterials, our understanding of how these molecules interact with antibiotics and impact resistance evolution remains unknown. Here, we investigated the propensity of three Escherichia coli strains to evolve resistance against pyoverdine, the cephalosporin antibiotic ceftazidime, and their combination. We used a naive E. coli wildtype strain and two isogenic variants carrying

SUBMITTER: Vollenweider V 

PROVIDER: S-EPMC11536758 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature