Menopausal hormone therapy and incidence, mortality, and survival of breast cancer subtypes: a prospective cohort study.

ABSTRACT:

Background

Menopausal hormone therapy (MHT) is associated with an increased risk of postmenopausal breast cancer, predominantly the luminal A-like subtype. The impact of MHT on deaths from breast cancer subtypes is less understood. This study aimed to explore associations between MHT use and the incidence, mortality, and survival of intrinsic-like breast cancer subtypes.

Methods

Data from 160,881 participants with self-reported MHT use from the prospective Norwegian Women and Cancer Study were analyzed. Among them, 7,844 incident breast cancer cases, and 721 breast cancer-specific deaths occurred. Cox proportional hazard regression was performed to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between MHT use and the incidence, mortali

SUBMITTER: Busund M 

PROVIDER: S-EPMC11536865 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature