MSC-microvesicles protect cartilage from degradation in early rheumatoid arthritis via immunoregulation.

ABSTRACT:

Objective

As research into preclinical rheumatoid arthritis (pre-RA) has advanced, a growing body of evidence suggests that abnormalities in RA-affected joint cartilage precede the onset of arthritis. Thus, early prevention and treatment strategies are imperative. In this study, we aimed to explore the protective effects of mesenchymal stem cell (MSC)-derived microvesicles (MVs) on cartilage degradation in a collagen-induced arthritis (CIA) mouse model.

Methods

A CIA mouse model was established to observe early pathological changes in cartilage (days 21-25) through histological and radiological examinations. On day 22, MSCs-MVs were intravenously injected into the mice with CIA. Radiological, histological, and flow cytometric examinations were conducted to observe inflammati

SUBMITTER: Wei S 

PROVIDER: S-EPMC11536868 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature