GATA2 deficiency and hemophagocytic lymphohistiocytosis (HLH): a systematic review of reported cases.

ABSTRACT:

Purpose

GATA2 deficiency is an autosomal dominant disease that manifests with a range of clinical symptoms, including increased susceptibility to viral, bacterial, and fungal infections. Furthermore, the increased susceptibility to infections in GATA2 deficiency can trigger hemophagocytic lymphohistiocytosis (HLH) in these patients. Our systematic review evaluates reported cases of GATA2 deficiency and HLH in the literature.

Methods

A systematic review of case reports was conducted following PRISMA 2020 guidelines, encompassing studies retrieved from Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science, and Google Scholar from inception until June 14, 2024. This review included studies reporting patients diagnosed with GATA2 deficiency or having a documented history

SUBMITTER: Rukerd MRZ 

PROVIDER: S-EPMC11536883 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature