Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli.

ABSTRACT:

Background

Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most functional microproteins were chosen for characterization because of their evolutionary conservation. However, one example of a non-conserved immunomodulatory microprotein in mice suggests that strict sequence conservation misses some intriguing microproteins.

Results

We examine the ability of gene regulation to identify human microproteins with potential roles in inflammation or fibrosis of the intestine. To do this, we collected ribosome profiling data of intestinal cell lines and peripheral blood mononuclear cells and used gene expression of

SUBMITTER: Pai VJ 

PROVIDER: S-EPMC11536906 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature