First detection of VEB-1 extended-spectrum β-lactamase-producing Escherichia coli clinical isolate in Japan.

ABSTRACT: The extended-spectrum β-lactamase (ESBL) gene, bla_VEB-1, was identified for the first time in an Escherichia coli clinical isolate, JARB-RN-0061, from blood cultures in a Japanese general hospital in 2021. The isolate exhibited high resistance to broad-spectrum cephalosporins, including ceftazidime (MIC >128 mg/L) and cefepime (MIC = 16 mg/L). bla_VEB-1 was identified during whole-genome sequencing and characterization of the isolate. JARB-RN-0061 belonged to the B2-O2:K1:H7-ST95-fimH41 lineage and was classified as presumptive extraintestinal pathogenic E. coli (ExPEC) and uropathogenic E. coli (UPEC). Moreover, the strain harbored multiple virulence genes on the chromosome. The Col156/IncFIB(AP001918)/IncFII(29)-type plasmid

SUBMITTER: Shindou J 

PROVIDER: S-EPMC11537020 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature