Association of the gut microbiome and different phenotypes of COPD and asthma: a bidirectional Mendelian randomization study.

ABSTRACT: Mounting evidence has revealed the association between gut microbiota and both chronic obstructive pulmonary disease (COPD) and asthma; however, the causal association between gut microbiota and specific disease phenotypes remains to be determined. This study employed bidirectional two-sample Mendelian randomization (MR) analyses to investigate the potential causal relationship between gut microbiota and these conditions. The research utilized genome-wide association study (GWAS) data from the MiBioGen consortium for gut microbiota and the integrative epidemiology unit (IEU) Open GWAS for these conditions. Four MR analysis methods were employed: the inverse variance weighted (IVW) test, MR-Egger, weighted median, and weighted mode methods. The IVW method results are considered the primary

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11537028 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature