Genomic characterization and clinical evaluation of prosthetic joint infections caused by <i>Cutibacterium acnes</i>.

ABSTRACT: Cutibacterium acnes is a major skin commensal that may act as an opportunistic pathogen. It is difficult to interpret findings of C. acnes in tissue cultures obtained during arthroplasty revision surgery, since they may represent true infection or contamination. This study investigated whether C. acnes obtained from prosthetic joint infections (PJIs) were related and shared common genomic traits that might correlate with clinical courses and patient outcomes. C. acnes isolates from revision surgery of patients with PJIs of the hip, shoulder, and knee were characterized using molecular methods to determine the sequence type (ST) and the presence of possible virulence determinants (Christie-Atkins-Munch-Peterson factors, dermatan sulfate-binding adhesion 1, hyalur

SUBMITTER: Liew-Littorin C 

PROVIDER: S-EPMC11537072 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature