Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in <i>Aspergillus niger</i>.

ABSTRACT: For over a century, the filamentous Ascomycete fungus Aspergillus niger has played a pivotal role in the industrial production of citric acid. A critical fermentation parameter that sustains high-yield citric acid accumulation is the suboptimal concentration of manganese(II) ions in the culture broth at the early stages of the process. However, the requirement for this deficiency has not been investigated on a functional genomics level. In this study, we compared the transcriptome of the citric acid hyper-producer A. niger NRRL2270 strain grown under citric acid-producing conditions in 6-L scale bioreactors at Mn²⁺ ion-deficient (5 ppb) and Mn²⁺ ion-sufficient (100 ppb) conditions at three early time points of cultivation. Of the 11,846 genes in the geno

SUBMITTER: Fekete E 

PROVIDER: S-EPMC11537073 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature