Ume6-dependent pathways of morphogenesis and biofilm formation in Candida auris.

ABSTRACT: Candida auris is a yeast pathogen causing nosocomial outbreaks of candidemia. Its ability to adhere to inert surfaces and to be transmitted from one patient to another via medical devices is of particular concern. Like other Candida spp., C. auris has the ability to transition from the yeast form to pseudohyphae and to build biofilms. Moreover, some isolates have a unique capacity to form aggregates. These morphogenetic changes may impact virulence. In this study, we demonstrated the role of the transcription factor Ume6 in C. auris morphogenesis. Genetic hyperactivation of Ume6 induced filamentation and aggregation. The Ume6-hyperactivated strain (UME6^HA) also exhibited increased adhesion to inert surface and formed biofilms of higher biomass

SUBMITTER: Louvet M 

PROVIDER: S-EPMC11537075 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature