Guanabenz acetate, an antihypertensive drug repurposed as an inhibitor of <i>Escherichia coli</i> biofilm.

ABSTRACT: Biofilms formed by Escherichia coli are composed of amyloid curli and cellulose and have been shown to be linked to pathogenicity, antibiotic resistance, and chronic infections. Guanabenz acetate (GABE), an antihypertensive drug, was identified as a potential strategic repurposing drug due to its biofilm inhibitory properties following an extensive antimicrobial screening assay of 2,202 Food and Drug Administration-approved non-antibiotic agents. The results of this study provide insights into the effectiveness of GABE as a therapeutic alternative against E. coli biofilm-associated infectious diseases.

Importance

Biofilm-associated bacterial infections are one of the major problems in medical settings. There are currently limited biofilm inhibitors available for clinic

SUBMITTER: Farha AK 

PROVIDER: S-EPMC11537090 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature