AmpC induction by imipenem in <i>Pseudomonas aeruginosa</i> occurs in the absence of OprD and impacts imipenem/relebactam susceptibility.

ABSTRACT: In the United States, carbapenem resistance in Pseudomonas aeruginosa is linked to the regulation of chromosomal resistance determinants, AmpC and OprD. The β-lactamase AmpC requires overexpression and genetic modifications to be capable of inhibiting imipenem activity. The outer membrane porin OprD can be downregulated or undergo genetic modifications that strongly correlate with imipenem non-susceptibility. Co-administration of imipenem and the β-lactamase inhibitor, relebactam, can lower imipenem minimal inhibitory concentrations and restore susceptibility. However, it is not understood how this occurs in P. aeruginosa isolates that do not overproduce AmpC or produce a functional OprD for imipenem entry. Therefore, we investigated whether imipenem could enter P. aerugin

SUBMITTER: Freed S 

PROVIDER: S-EPMC11537110 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature