Socioeconomic status moderates associations between hippocampal development and cognition in preterms.

ABSTRACT:

Objective

The hippocampus plays a critical role in cognitive networks. The anterior hippocampus is vulnerable to early-life stress and socioeconomic status (SES) with alterations persisting beyond childhood. How SES modifies the relationship between early hippocampal development and cognition remains poorly understood. This study examined associations between SES, structural and functional development of neonatal hippocampus, and 18-month cognition in very preterm neonates.

Methods

In total, 179 preterm neonates were followed prospectively. Structural and resting-state functional MRI were obtained early-in-life and at term-equivalent age (median 32.9 and 41.1 weeks post-menstrual age) to calculate anterior and posterior hippocampal volumes and hippocampal functional connecti

SUBMITTER: Konrad J 

PROVIDER: S-EPMC11537128 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature