Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation.

ABSTRACT: Identification of tissue-specific gene regulatory networks can yield insights into the molecular basis of a tissue's development, function and pathology. Here, we present a computational approach designed to identify potential regulatory target genes of photoreceptor cell-specific transcription factors (TFs). The approach is based on the hypothesis that genes related to the retina in terms of expression, disease and/or function are more likely to be the targets of retina-specific TFs than other genes. A list of genes that are preferentially expressed in retina was obtained by integrating expressed sequence tag, SAGE and microarray datasets. The regulatory targets of retina-specific TFs are enriched in this set of retina-related genes. A Bayesian approach was employed to integrate informati

SUBMITTER: Qian J 

PROVIDER: S-EPMC1153713 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature