CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery.

ABSTRACT:

Objective

Treatment of pediatric brain tumors is associated with potential long-term cognitive sequelae. Patients treated with craniospinal irradiation for posterior fossa tumors are at high risk. New biomarkers that could help to differentiate treatment effects from other causes of cognitive dysfunction would be valuable in tailoring optimal survivorship care. Biomarkers that reflect biological mechanisms behind treatment-associated cognitive decline would also be important in the evaluation of future treatment regimens for pediatric brain or skull base tumors.

Methods

In this biomarker-finding study, 10 adult survivors of pediatric medulloblastoma, skull base tumors, and posterior fossa low-grade glioma underwent study specific lumbar puncture at a minimum of 17 years foll

SUBMITTER: Fernstrom E 

PROVIDER: S-EPMC11537133 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature