Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network.

ABSTRACT:

Objective

The first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these criteria to a prospective, global observational study of acute optic neuritis (ON).

Methods

We included 160 patients with a first-ever acute ON suggestive of a demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). We applied the 2022 ICON to all participants and subsequently adjusted the ICON by replacing a missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology of the optical nerve plus optical coherence tomography abnormalities or certain biomarkers are present.

Results

According to the 2022 ICON, 80 (50%) patients were classified as definite ON, 12 (7%) patients were classified

SUBMITTER: Klyscz P 

PROVIDER: S-EPMC11537134 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature