Investigating cortical hypoxia in multiple sclerosis via time-domain near-infrared spectroscopy.

ABSTRACT:

Objectives

Hypoperfusion and tissue hypoxia have been implicated as contributory mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to study cortical oxygenation in vivo in patients with MS and age-matched controls.

Methods

A custom, multiwavelength time-domain near-infrared spectroscopy system was developed for assessing tissue hypoxia from the prefrontal cortex. A cross-sectional case-control study was undertaken assessing patients with secondary progressive MS (SPMS) and age-matched controls. Co-registered magnetic resonance imaging was used to verify the location from which near-infrared spectroscopy data were obtained through Monte Carlo simulations of photon propagation. Additional clinical assessments of MS disease severity were carrie

SUBMITTER: Williams T 

PROVIDER: S-EPMC11537135 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature