Exploring postictal recovery with acetaminophen or nimodipine: A randomized-controlled crossover trial.

ABSTRACT:

Objective

The postictal state is underrecognized in epilepsy. Animal models show improvement of postictal symptoms and cerebral perfusion with acetaminophen or nimodipine. We studied the effects of acetaminophen or nimodipine on postictal electroencephalographic (EEG) recovery, clinical reorientation, and hypoperfusion in patients with ECT-induced seizures.

Methods

In this prospective clinical trial with three-condition randomized crossover design, study interventions were administered orally 2 h before ECT sessions (1000 mg acetaminophen, 60 mg nimodipine, or a placebo condition). Primary outcome measure was the speed of postictal EEG recovery. Secondary outcomes were the extent of postictal EEG recovery, clinical reorientation time, and postictal cerebral blood flow as ass

SUBMITTER: Pottkamper JCM 

PROVIDER: S-EPMC11537141 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature