Neutrophil-to-lymphocyte ratio and longitudinal cognitive performance in Parkinson's disease.

ABSTRACT:

Objective

Previous studies have suggested a link between peripheral inflammation and cognitive outcomes in the general population and individuals with Parkinson's disease (PD). We sought to test the association between peripheral inflammation, measured by the neutrophil-to-lymphocyte ratio (NLR), cognitive performance, and mild cognitive impairment (MCI) status in individuals with PD.

Methods

A retrospective, longitudinal analysis was carried out using data from the Parkinson's Progression Markers Initiative (PPMI), including 422 participants with PD followed over 5 years. Cognitive performance was assessed using a neuropsychological battery including the Montreal Cognitive Assessment (MoCA) and tests of verbal learning, visuospatial function, processing speed, and executive

SUBMITTER: Lucero J 

PROVIDER: S-EPMC11537143 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature