Axonal injury, sleep disturbances, and memory following traumatic brain injury.

ABSTRACT:

Objectives

Traumatic brain injury (TBI) is associated with sleep deficits, but it is not clear why some report sleep disturbances and others do not. The objective of this study was to assess the associations between axonal injury, sleep, and memory in chronic and acute TBI.

Methods

Data were acquired from two independent datasets which included 156 older adult veterans (69.8 years) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with prior moderate-to-severe TBIs and 90 (69.2 years) controls and 374 (39.6 years) from Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) with a recent mild TBI (mTBI) and 87 controls (39.6 years), all who completed an MRI, memory assessment, and sleep questionnaire.

Results

Older adults with a prior TBI had a signi

SUBMITTER: Tinney EM 

PROVIDER: S-EPMC11537145 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature