Chromosome architecture as a determinant for biosynthetic diversity in Micromonospora.

ABSTRACT: Natural products - small molecules generated by organisms to facilitate ecological interactions - are of great importance to society and are used as antibacterial, antiviral, antifungal and anticancer drugs. However, the role and evolution of these molecules and the fitness benefits they provide to their hosts in their natural habitat remain an outstanding question. In bacteria, the genes that encode the biosynthetic proteins that generate these molecules are organised into discrete loci termed biosynthetic gene clusters (BGCs). In this work, we asked the following question: How are biosynthetic gene clusters organised at the chromosomal level? We sought to answer this using publicly available high-quality assemblies of Micromonospora, an actinomycete genus with members responsible

SUBMITTER: Mark DR 

PROVIDER: S-EPMC11537254 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature