Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.

ABSTRACT: The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system. We tested and validated each model component and the final network model, and made input data, assumptions, and strategies ex

SUBMITTER: Romani A 

PROVIDER: S-EPMC11537418 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature