SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus.

ABSTRACT: The epigenetic reader SntB was identified as an important transcriptional regulator of growth, development, and secondary metabolite synthesis in Aspergillus flavus. However, the underlying molecular mechanism is still unclear. In this study, by gene deletion and complementation, we found SntB is essential for mycelia growth, conidial production, sclerotia formation, aflatoxin synthesis, and host colonization. Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) analysis revealed that SntB played key roles in oxidative stress response of A. flavus, influencing related gene activity, especially catC encoding catalase. SntB regulated the expression activity of catC with or without oxidative stress, and was related to the expression leve

SUBMITTER: Wu D 

PROVIDER: S-EPMC11537487 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature