Brain reward response in adolescents and young adults with anorexia nervosa is moderated by changes in body weight and sweetness perception.

ABSTRACT:

Objective

Anorexia nervosa (AN) is a severe psychiatric illness with complex etiology. Recently, we found elevated striatal brain response to sweet taste stimuli in adolescents and young adults with AN. Here, we tested the hypothesis that nutritional rehabilitation normalizes prediction error activation, a measure for dopamine-related reward circuit response, to salient caloric taste stimuli in AN.

Methods

A total of 28 individuals with AN (age = 16 ± 2 years; body mass index [BMI] = 16 ± 1) who previously underwent brain imaging while performing a taste prediction error task using sucrose as salient caloric stimulus, participated in a second brain imaging scan (BMI = 18 ± 1) after intensive specialized eating disorder treatment (41 ± 15 days). A total of 31 healthy controls

SUBMITTER: Frank GKW 

PROVIDER: S-EPMC11537494 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature