Transplant Candidate Outcomes After Declining a DCD Liver in the United States.

ABSTRACT:

Background

In the context of the organ shortage, donation after circulatory death (DCD) provides an opportunity to expand the donor pool. Although deceased-donor liver transplantation from DCD donors has expanded, DCD livers continue to be discarded at elevated rates; the use of DCD livers from older donors, or donors with comorbidities, is controversial.

Methods

Using US registry data from 2009 to 2020, we identified 1564 candidates on whose behalf a DCD liver offer was accepted ("acceptors") and 16 981 candidates on whose behalf the same DCD offers were declined ("decliners"). We characterized outcomes of decliners using a competing risk framework and estimated the survival benefit (adjusted hazard ratio [95% confidence interval]) of accepting DCD livers using Cox regressi

SUBMITTER: Ishaque T 

PROVIDER: S-EPMC11537495 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature