Impact of immune cells on the risk of frozen shoulder: A 2-sample Mendelian randomization study.

ABSTRACT: The pathogenesis of frozen shoulder (FS) remains unclear, and current research primarily focuses on immune responses. Increasing evidence suggests that immune cells play a significant role in FS development. However, the causal relationship between the two remains poorly understood. Therefore, we aimed to investigate this using Mendelian randomization (MR) analysis. Single nucleotide polymorphisms closely associated with 731 immune phenotypes were obtained from publicly available GWAS datasets as instrumental variables. FS was used as the outcome with a sample size of 451,099 cases. Causal effects were analyzed using the inverse variance-weighted method. We conducted sensitivity tests, including the intercept of the MR-Egger and MR-PRESSO analyses. The presence of heterogeneity was evaluat

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11537608 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature