Association between dried fruit intake and kidney function: research from univariate and multivariate Mendelian randomized studies.

ABSTRACT:

Objectives

Observational studies have identified an association between dried fruit intake and kidney function. However, these studies have limitations such as vulnerability to confounders and reverse causality bias. Therefore, this study aimed to explore the potential causal relationship between dried fruit intake and kidney function.

Methods

A two-sample Mendelian randomization (MR) study was conducted using a large-scale genome-wide association study dataset to investigate the causal relationship between dried fruit intake and kidney function markers (blood urea nitrogen (BUN), creatinine (CR), uric acid (UA), cystatin C (CyC), hematuria, microalbuminuria). The main analytical method was inverse variance weighting. In addition, we applied the MR Egger and weighted median

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11537924 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature