Downregulation of <i>BmSTAT</i> transcription factor promoted nucleopolyhedrovirus replication in <i>Bombyx mori</i>.

ABSTRACT: The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a crucial role in the viral immune processes of organisms, with STAT being a key transcription factor downstream in this pathway. The STAT gene of Bombyx mori has two splicing forms, named BmSTAT-S and BmSTAT-L. This study compared the effects of the two splicing forms on Bombyx mori nucleopolyhedrovirus (BmNPV) infection through cell-level interference and further explored whether BmSTAT participates in the immune response to BmNPV infection via transgenic intervention at the individual level. Our research results indicated that BmNPV upregulates the expression of BmSTAT-S and BmSTAT-L in Bombyx mori BmE cells and larvae. Furth

SUBMITTER: Liang W 

PROVIDER: S-EPMC11537930 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature