Stem cell-derived exosomes for ischemic stroke: a conventional and network meta-analysis based on animal models.

ABSTRACT:

Objective

We aimed to evaluate the efficacy of stem cell-derived exosomes for treating ischemic stroke and to screen for the optimal administration strategy.

Methods

We searched PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases for relevant studies published from their inception to 31 December 2023. Conventional and network meta-analyses of the routes of administration, types, and immune compatibility of stem cell-derived exosomes were performed using the cerebral infarct volume (%) and modified neurological severity score (mNSS) as outcome indicators.

Results

A total of 38 randomized controlled animal experiments were included. Conventional meta-analysis showed that compared with the negative control group: intravenous administration significantl

SUBMITTER: Xu K 

PROVIDER: S-EPMC11537945 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature