Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.

ABSTRACT: Germinal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture remains unknown. Here we show that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduces angiogenesis in the ganglionic eminences, which correspond to the human germinal matrix. Consistent with these findings, single-cell transcriptomics and flow cytometry show that distinct subsets of CD45⁺ cells from control preterm infants employ diverse signaling mechanisms to promote vascular network formation. In contrast, CD45⁺ cells from infants with GMH harbor activated neutrophils and monocytes that produ

SUBMITTER: Chen J 

PROVIDER: S-EPMC11537974 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature