Target antigen screening and development of a multi-component subunit vaccine against Mycoplasma synoviae in chickens.

ABSTRACT:

Introduction

Mycoplasma synoviae (MS) is a globally important avian pathogen causing infectious synovitis and respiratory diseases in poultry, leading to significant economic losses. Despite advances in vaccine development, a commercially viable subunit vaccine against MS remains elusive.

Methods

We sequenced whole genomes of six clinical MS strains isolated from different Chinese provinces. Common genes were analyzed using Biopython software, identifying those with high copy numbers in virulent strains and shared among all strains. Vaxign2 and IEDB Antibody Epitope Prediction were used to analyze protein properties. We assessed immune protective effects of candidate proteins and developed a multivalent subunit vaccine.

Results

Ten candidate vaccine proteins we

SUBMITTER: Sun X 

PROVIDER: S-EPMC11537996 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature