Suicidal behavior in ADHD: the role of comorbidity, psychosocial adversity, personality and genetic factors.

ABSTRACT: Adult ADHD is associated with increased risk for suicide attempts, as indicated by investigations of population- and community-based cohorts. However, there is little data regarding suicide attempts in a clinical setting. To address this, we used a comprehensively phenotyped clinical adult ADHD (aADHD) cohort to assess to which extent comorbidity, psychosocial adversity, personality, and ADHD symptoms contribute to suicidal behavior in ADHD. Furthermore, we investigated a triallelic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR), which has previously been associated with suicidal behavior. Depression, substance use, eating, and posttraumatic stress disorders were independently associated with past suicide attempts, whereas anxiety, somatoform, and obsessive-com

SUBMITTER: Ziegler GC 

PROVIDER: S-EPMC11538115 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature