Update on the role of S100B in traumatic brain injury in pediatric population: a meta-analysis.

ABSTRACT:

Objective

Cranial computed tomography (CT) scan is the most widely used tool to rule out intracranial lesions after pediatric traumatic brain injury (TBI). However, in pediatric population, the radiation exposure can lead to an increased risk of hematological and brain neoplasm. Defined in 2019 National Institute for Health and Care Excellence (NICE) guidelines as "troponins for the brain", serum biomarkers measurements, particularly S100B, have progressively emerged as a supplementary tool in the management of TBI thanks to their capacity to predict intracranial post-traumatic lesions.

Methods

This systematic review was conducted following the PRISMA protocol (preferred reporting items for systematic reviews and meta-analyses). No chronological limits of study publications

SUBMITTER: Morello A 

PROVIDER: S-EPMC11538191 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature