Exploring a tristhione scorpionate ligand as a suitable chelator for the theranostic pair antimony-119 and antimony-117.

ABSTRACT:

Background

The highly potent Auger electron emitter antimony-119 (¹¹⁹Sb) and the SPECT-isotope antimony-117 (¹¹⁷Sb) comprise a true theranostic pair particularly suitable for cancer theranostics. Harnessing this potential requires development of a chelator that can rapidly form a stable complex with radioactive antimony ions at the low concentrations typical of radiopharmaceutical preparations. Stable Sb(III) complexes of hydrotris(methimazolyl)borate (TMe) are known, prompting our investigation of this chelator. Additionally, the production of radioantimony was optimized and the SPECT imaging properties of ¹¹⁷Sb was investigated, in an attempt to move towards biomedical implementation of the theranostic isotope pair of antimony.

Results

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SUBMITTER: Ge LG 

PROVIDER: S-EPMC11538217 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature