Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment.

ABSTRACT: In the first days of life, the newborns' intestinal microbiota develops simultaneously with the intestinal gut barrier and follows intestinal immunity. The mode of delivery shows significant impact on microbial development and, thus, the initiation of the tryptophan catabolism pathway. Further antibiotics (ATB) treatment of mothers before or during delivery affects the microbial and tryptophan metabolite composition of stool of the caesarean- and vaginal-delivered newborns. The determination of microbiome and levels of tryptophan microbial metabolites in meconium and stool can characterize intestinal colonization of a newborn. From 134 samples from the Central European Longitudinal Studies of Parents and Children: The Next Generation (CELSPAC: TNG) cohort study, 16S rRNA gene sequencing wa

SUBMITTER: Aust AC 

PROVIDER: S-EPMC11538234 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature