Atomically precise copper clusters with dual sites for highly chemoselective and efficient hydroboration.

ABSTRACT: The hydroboration of alkynes into vinylboronate esters is a vital transformation, but achieving high chemoselectivity of targeted functional groups and an appreciable turnover number is a considerable challenge. Herein, we develop two dynamically regulating dual-catalytic-site copper clusters (Cu₄NC and Cu₈NC) bearing N-heterocyclic thione ligands that endow Cu₄NC and Cu₈NC catalysts with performance. In particular, the performance of microcrystalline Cu₄NC in hydroboration is characterized by a high turnover number (77786), a high chemoselectivity, high recovery and reusability under mild conditions. Mechanistic studies and density functional theory calculations reveal that, compared with the Cu₈NC catalyst, the Cu₄

SUBMITTER: Jia T 

PROVIDER: S-EPMC11538399 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature