The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow.

ABSTRACT: We consider how the genetic architecture underlying locally adaptive traits determines the strength of a barrier to gene flow in a mainland-island model. Assuming a general life cycle, we derive an expression for the effective migration rate when local adaptation is due to genetic variation at many loci under directional selection on the island, allowing for arbitrary fitness and dominance effects across loci. We show how the effective migration rate can be combined with classical single-locus diffusion theory to accurately predict multilocus differentiation between the mainland and island at migration-selection-drift equilibrium and determine the migration rate beyond which local adaptation collapses, while accounting for genetic drift and weak linkage. Using our efficient numerical tools

SUBMITTER: Zwaenepoel A 

PROVIDER: S-EPMC11538419 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature