A mixed animal and plant protein source replacing fishmeal affects bile acid metabolism and apoptosis in largemouth bass (Micropterus salmoides).

ABSTRACT: Chicken meal, shrimp meal, blood meal, and soybean protein concentrate are common alternatives to fishmeal. This study used them to prepare three diets with different levels of fishmeal (FM48, FM40, and FM32) for largemouth bass (Micropterus salmoides). The results found no significant difference in the growth performance of largemouth bass fed different diets. Mixed protein increased the total cholesterol (T-CHO) content in plasma, and reduced the total superoxide dismutase (T-SOD) activity in plasma and liver. Targeted metabolomics analysis found that the low fishmeal diets affected the cholesterol and bile acid metabolism of largemouth bass. Mixed protein inhibited cyp7a1 and enhanced hmgcr and pparγ mRNA levels, as well as enhanced the expression levels of FXR in the liver. The fish-fe

SUBMITTER: Chen L 

PROVIDER: S-EPMC11538531 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature