LC-MS/MS analysis reveals plasma protein signatures associated with lymph node metastasis in colorectal cancer.

ABSTRACT:

Objectives

Colorectal cancer (CRC) is a major global health concern, ranking as the third most common cancer and the fourth leading cause of cancer-related deaths worldwide. Currently, the diagnostic accuracy of Lymph node metastasis (LNM) is currently unsatisfactory. Therefore, there is an urgent need to develop a reliable tool that can accurately predict lymph node metastasis (LNM) in patients diagnosed with CRC.

Methods

We conducted an extensive proteomics investigation aimed at examining lymph node metastasis (LNM) in individuals diagnosed with colorectal cancer (CRC). In the discovery stage, employing a mass spectrometry-based proteomic approach, we analyzed a cohort of 60 colorectal cancer patients (NM=30, LNM=30), identifying distinct molecular profiles that different

SUBMITTER: Pang C 

PROVIDER: S-EPMC11538601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature